Study Title
Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review
Principal Investigator
Esmeralda Josa, Guillermina Barril, Mar Ruperto
Affiliation
Universidad Complutense de Madrid, Spain; Fundación Investigaciones Biomédicas, Spain; Universidad San Pablo-CEU, Spain
Start Date
Not specified
End Date
Not specified
Study Objective
To assess the effects of bioactive compounds from plant-based foods and medicinal plants in chronic kidney disease (CKD) and dialysis patients, focusing on their antioxidant, anti-inflammatory, and renoprotective properties.
Short Abstract
This systematic review analyzes 23 randomized clinical trials (RCTs) and their findings on various plant-based bioactive compounds, such as curcumin, propolis, sulforaphane, and others, in the context of CKD and dialysis. The review highlights the potential therapeutic effects of these compounds in reducing oxidative stress, inflammation, and improving kidney function, though further research is recommended for clinical applications.
Study Design
Systematic review of RCTs
Population
Chronic kidney disease (CKD) patients and dialysis patients
Sample Size
The review includes 23 RCTs
Inclusion Criteria
Human studies, randomized clinical trials, bioactive compounds from plant-based foods and medicinal plants in CKD and dialysis patients
Exclusion Criteria
Animal studies, studies not focusing on plant-based bioactive compounds or medicinal plants
Intervention/Exposure
Bioactive compounds including curcumin, propolis, sulforaphane, betalain, genistein, allicin, and medicinal plants like green tea, rhubarb, Astragalus membranaceus, and Tripterygium wilfordii
Outcome Measures
- Anti-inflammatory effects
- Antioxidant effects
- Renoprotective properties
- Improvements in kidney function and biomarkers (e.g., proteinuria, glomerular filtration rate)
Funding Source
Not specified
Collaborating Institutions
Universidad Complutense de Madrid, Fundación Investigaciones Biomédicas, Universidad San Pablo-CEU
Ethics Approval
Not specified
Publication Status
Published in Nutrients (2024)
Keywords
Chronic kidney disease, plant-based foods, medicinal plants, bioactive compounds, inflammation, oxidative stress
Data Collection Methods
Systematic search in PubMed, LILACS, Embase, Scopus, Web of Science between December 2022 and October 2024
Primary Data Availability
Not applicable
Contact Information
Esmeralda Josa: