Study Title
Nutritional Prehabilitation Intervention in Hematological Patients Undergoing Bone Marrow Transplant: A Systematic Review of the Literature
Principal Investigator
Luca Falcone, Stefano Mancin, Elena Azzolini, Francesco Colotta, Sergio Ferrante, Manuela Pastore, Sara Morales Palomares, Diego Lopane, Marco Sguanci, Simone Cosmai, Daniela Cattani, Emanuele Cereda, Riccardo Caccialanza, Beatrice Mazzoleni
Affiliation
Humanitas University, Milan, Italy; IRCCS Humanitas Research Hospital, Milan, Italy; University of Calabria, Italy; Polyclinic San Martino Hospital, Genoa, Italy; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Start Date
Not specified
End Date
Not specified
Study Objective
To evaluate the effectiveness of nutritional prehabilitation interventions in hematological patients undergoing bone marrow transplant (BMT) to mitigate malnutrition and improve clinical outcomes.
Short Abstract
This systematic review examines various nutritional prehabilitation strategies used in BMT patients, including counseling, protein supplementation, and oral nutritional supplements (ONS). The findings show that pre-transplant nutritional support significantly improves energy intake, reduces complications such as pneumonia and graft-versus-host disease, and shortens hospital stays. Despite the evidence, the variability in methodologies and the lack of standardized protocols highlight the need for further studies.
Study Design
Systematic review
Population
Hematological patients undergoing bone marrow transplant
Sample Size
366 patients across six studies
Inclusion Criteria
Quantitative studies on nutritional prehabilitation interventions for BMT patients
Exclusion Criteria
Narrative reviews, meta-analyses, studies without full text, or those not focusing on nutritional interventions
Intervention/Exposure
- Nutritional counseling
- Protein supplementation
- Oral nutritional supplements (ONS)
- Elemental diets
Outcome Measures
- Energy intake and nutritional status
- Length of hospital stay (LOS)
- Incidence of clinical complications (e.g., pneumonia, graft-versus-host disease)
- Mortality and survival rates
Funding Source
Not specified
Collaborating Institutions
Humanitas University, IRCCS Humanitas Research Hospital, University of Calabria, Polyclinic San Martino Hospital, Fondazione IRCCS Policlinico San Matteo
Ethics Approval
Not specified
Publication Status
Published in Nutrients (2024)
Keywords
Bone marrow transplant, nutritional prehabilitation, malnutrition, protein supplementation, clinical outcomes, graft-versus-host disease
Data Collection Methods
Systematic search in PubMed, Cochrane Library, CINAHL, and Embase
Primary Data Availability
Not applicable
Contact Information
Emanuele Cereda: