Study Title
Effects of Enteral Insulin on Enteral Diet Tolerance in Premature Infants: Systematic Review
Principal Investigator
Letícia Baciuk-Souza, Laura Ferrer Del Pra, Luca Schiliró Tristão, Mayco José Reinaldi Serra, Vera Esteves Vagnozzi Rullo
Affiliation
Fundação Lusíada, Faculdade de Ciências Médicas de Santos, Santos, SP, Brazil
Start Date
Not specified
End Date
Not specified
Study Objective
To evaluate the effect of enteral insulin supplementation provided to premature newborns on the time to achieve full enteral feeding (FEF), as well as the effects on weight gain, adverse events, and mortality.
Short Abstract
This systematic review investigates the impact of enteral insulin on the time taken to achieve full enteral feeding in premature infants, along with secondary outcomes including weight gain, adverse events, and mortality. The findings indicate that enteral insulin reduces the time to achieve full enteral feeding, with a reduction in parenteral nutrition use, adverse events, and mortality. However, no consensus was found regarding weight gain.
Study Design
Systematic review of randomized clinical trials
Population
Premature infants receiving enteral and parenteral nutrition
Sample Size
Two studies included, but the total sample size is not specified
Inclusion Criteria
Premature infants receiving breast milk or formula supplemented with enteral insulin as intervention compared to placebo.
Exclusion Criteria
Studies with children with major congenital malformations, necrotizing enterocolitis, neonatal sepsis, or those using parenteral insulin
Intervention/Exposure
Enteral insulin supplementation in premature infants
Outcome Measures
- Time to achieve full enteral feeding (FEF)
- Days receiving parenteral nutrition
- Weight gain
- Adverse events (e.g., hypoglycemia, necrotizing enterocolitis)
- Mortality
Funding Source
The study did not receive any funding
Collaborating Institutions
Fundação Lusíada, Faculdade de Ciências Médicas de Santos, Santos, SP, Brazil
Ethics Approval
Not specified
Publication Status
Published in Revista Paulista de Pediatria (2025)
Keywords
Premature infants, enteral insulin, enteral feeding, weight gain, mortality
Data Collection Methods
Systematic literature search in databases such as PubMed, SciELO, Embase, and Latin American Health Sciences
Primary Data Availability
Available with the corresponding author
Contact Information
Letícia Baciuk-Souza: