Study Title
Do Precision and Personalised Nutrition Interventions Improve Risk Factors in Adults with Prediabetes or Metabolic Syndrome? A Systematic Review of Randomised Controlled Trials
Principal Investigator
Seaton Robertson, Erin D. Clarke, María Gómez-Martín, Victoria Cross, Clare E. Collins, Jordan Stanford
Affiliation
The University of Newcastle, Australia; Hunter Medical Research Institute, Australia
Start Date
Not specified
End Date
Not specified
Study Objective
To evaluate the efficacy of precision and personalised nutrition (PPN) and medical nutrition therapy (MNT) interventions in improving risk factors associated with prediabetes and metabolic syndrome (MetS), including glycaemic control, anthropometry, blood lipids, blood pressure, and dietary intake.
Short Abstract
This systematic review examines seven randomised controlled trials (RCTs) investigating the impact of precision and personalised nutrition (PPN) and medical nutrition therapy (MNT) on adults with prediabetes or metabolic syndrome (MetS). The findings show significant improvements in glycaemic control (HbA1c, post-prandial glucose) and waist circumference following PPN and MNT interventions, but inconsistent results for other measures such as fasting blood glucose, blood lipids, and blood pressure. The review suggests that longer, more frequent interventions are associated with greater improvements.
Study Design
Systematic review of randomised controlled trials (RCTs)
Population
Adults with prediabetes or metabolic syndrome
Sample Size
873 participants across seven RCTs
Inclusion Criteria
Adults diagnosed with prediabetes or metabolic syndrome; RCTs with PPN or MNT interventions targeting glycaemic control, anthropometry, blood lipids, blood pressure, and dietary intake
Exclusion Criteria
Studies that included medications, physical activity, or other lifestyle interventions not focused on diet; studies not in English
Intervention/Exposure
Personalised nutrition interventions (PPN), Medical Nutrition Therapy (MNT)
Outcome Measures
Glycaemic control (HbA1c, post-prandial glucose, fasting blood glucose), anthropometric measurements (BMI, waist circumference, weight), blood lipids, blood pressure, dietary intake
Funding Source
No external funding reported
Collaborating Institutions
The University of Newcastle, Hunter Medical Research Institute
Ethics Approval
Not applicable (systematic review)
Publication Status
Published in Nutrients, May 2024
Keywords
Precision nutrition, personalised nutrition, prediabetes, metabolic syndrome, medical nutrition therapy, systematic review, randomised controlled trial
Data Collection Methods
Systematic literature search using databases like Scopus, Medline, Embase, CINAHL, PsycINFO, and Cochrane
Primary Data Availability
Not applicable
Contact Information
Jordan Stanford (