Study Title
Genetic Variants Affecting Iron Metabolism in Healthy Adults: A Systematic Review to Support Personalized Nutrition Strategies
Principal Investigator
Elana Sophie Bösch, Jörg Spörri, Johannes Scherr
Affiliation
University Centre for Prevention and Sports Medicine, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Switzerland
Start Date
Not specified
End Date
Not specified
Study Objective
To identify genetic variants, particularly SNPs, that affect iron metabolism in healthy adults and their implications for personalized nutrition and supplementation strategies.
Short Abstract
This systematic review focuses on genetic variants associated with iron metabolism, specifically SNPs, and their impact on iron deficiency and anemia. Twenty-one studies were reviewed, revealing that several SNPs in the TMPRSS6 and HFE genes significantly affect iron parameters such as ferritin, transferrin, and hepcidin levels. The findings suggest that individuals carrying certain genetic variants may benefit from personalized iron supplementation strategies to optimize health outcomes.
Study Design
Systematic review
Population
Healthy adults
Sample Size
22,938 participants across 21 studies
Inclusion Criteria
Studies on genetic variants affecting iron metabolism in healthy adults, published between 2007 and 2023
Exclusion Criteria
Studies on overweight, diseased, or underage individuals, or those without validated results
Intervention/Exposure
Genetic variants (SNPs) affecting iron metabolism
Outcome Measures
Iron status markers: ferritin, transferrin, serum iron, TIBC, hepcidin, and the risk of iron deficiency or anemia
Funding Source
University Centre for Prevention and Sports Medicine at Balgrist University Hospital Zurich, Swiss Innovation Agency Innosuisse, European Research Council (ERC)
Collaborating Institutions
University of Zurich, Balgrist University Hospital
Ethics Approval
Not applicable (systematic review)
Publication Status
Published in Nutrients, November 2024
Keywords
Genetic variants, iron metabolism, SNPs, personalized nutrition, iron deficiency, nutrigenomics
Data Collection Methods
Systematic search through Cochrane, Embase, MEDLINE databases for English and German studies on genetic variants linked to nutrition
Primary Data Availability
Not applicable
Contact Information
Elana Sophie Bösch (