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Nutrition Interactions with COVID-19

These articles provide information on what is currently known about the nutrition interactions with the virus and its effects on the human body. A strong focus is also to understand how nutritional circumstances or interventions might mitigate the infections’ harm, both acutely and in the long term. The collection also showcases, and welcomes, good quality evidence studying the combination of diet and lifestyle factors that may strengthen immunity and susceptibility to the virus.
 

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Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study.

Details
Category: Nutrition Interactions with COVID-19
Hits: 45
ID: 62
  • Study Status: Published
  • Study Type: Mendelian randomisation
  • Study Location: Multicountry

Study Title
Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study.

Principal Investigator
Bonnie K Patchen, Andrew G Clark, Nathan Gaddis, Dana B Hancock, Patricia A Cassano.

Affiliation
Cornell University, Research Triangle Institute.

Start Date
February 2021.

End Date
April 2021.

Study Objective
To investigate the causality of the association between serum vitamin D levels and the risk and severity of COVID-19 infection.

Short Abstract
This study used Mendelian randomisation to examine the association between genetically predicted serum vitamin D levels and COVID-19 risk. It found little to no evidence that genetically predicted serum vitamin D affects the risk or severity of COVID-19. The findings suggest that previous observational studies may have been confounded by other factors.

Study Design
Two-sample Mendelian randomisation study using genome-wide analysis data from the UK Biobank and SUNLIGHT Consortium for serum vitamin D and the COVID-19 Host Genetics Initiative for COVID-19 outcomes.

Population
17,965 COVID-19 cases and 1,370,547 controls, primarily of European ancestry.

Sample Size
17,965 COVID-19 cases (including 11,085 confirmed cases and 7,885 hospitalised cases) and 1,370,547 controls.

Inclusion Criteria
Individuals with genome-wide data available, predominantly of European ancestry.

Exclusion Criteria
None mentioned.

Intervention/Exposure
Genetically predicted variation in serum vitamin D levels using single nucleotide polymorphisms (SNPs).

Outcome Measures

  • Susceptibility to COVID-19
  • Severity of COVID-19 infection (hospitalisation, severe respiratory infection)

Funding Source
Supported by the National Institutes of Health (NIH).

Collaborating Institutions
Cornell University, Research Triangle Institute.

Ethics Approval
Not required (used publicly available data).

Publication Status
Published in BMJ Nutrition, Prevention & Health, May 2021.

Keywords
Vitamin D, COVID-19, Mendelian randomisation, genetics, SARS-CoV-2.

Data Collection Methods
Genome-wide analysis from the UK Biobank and the COVID-19 Host Genetics Initiative.

Primary Data Availability
Data available publicly from UK Biobank and COVID-19 Host Genetics Initiative.

Contact Information
Dr. Patricia A Cassano, This email address is being protected from spambots. You need JavaScript enabled to view it..