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Nutrition and Cardiometabolic Health

The Nutrition and Cardiometabolic Health special collection aims to advance our understanding of how dietary patterns, macronutrient composition, micronutrient intake, and dietary supplements influence cardiometabolic risk factors. We welcome submissions that delve into various aspects of the relationship between nutrition and cardiometabolic health, including dietary patterns, macronutrient composition, micronutrient intake, and dietary supplements, with a focus on their impact on cardiovascular disease, metabolic syndrome, diabetes, and related conditions.
 

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Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-Analysis

Details
Category: Nutrition and Cardiometabolic Health
Hits: 27
ID: 94
  • Study Status: Published
  • Study Type: Review
  • Study Location: Global

Study Title
Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-Analysis

Principal Investigator
Fotios Barkas, Tzortzis Nomikos, Evangelos Liberopoulos, Demosthenes Panagiotakos

Affiliation
University of Ioannina, Greece; Harokopio University, Greece

Start Date
Not specified

End Date
Not specified

Study Objective
To assess the impact of cholesterol-lowering diets and other dietary interventions on the incidence or mortality of cardiovascular disease and lipid profile in individuals with familial hypercholesterolemia (FH).

Short Abstract
This systematic review and meta-analysis evaluated 17 trials involving 376 participants with familial hypercholesterolemia. It found that plant sterols and stanols effectively lower cholesterol levels, while omega-3 fatty acids reduce triglycerides. However, no studies reported on cardiovascular disease incidence or mortality.

Study Design
Systematic review and meta-analysis of randomized controlled trials (RCTs).

Population
Children and adults with familial hypercholesterolemia

Sample Size
376 participants across 17 trials

Inclusion Criteria
Randomized controlled trials assessing the effect of dietary interventions on lipid profiles in FH patients

Exclusion Criteria
Studies not focused on FH or not involving relevant dietary interventions

Intervention/Exposure
Cholesterol-lowering diet, omega-3 fatty acids, plant sterols, plant stanols, and other dietary modifications

Outcome Measures
Lipid profile changes (total cholesterol, LDL-C, triglycerides)

Funding Source
Not specified

Collaborating Institutions
University of Ioannina, Harokopio University

Ethics Approval
Not specified

Publication Status
Published in Nutrients (2020).

Keywords
Familial hypercholesterolemia, cholesterol-lowering diet, plant sterols, omega-3 fatty acids, dietary interventions, cardiovascular disease

Data Collection Methods
Systematic review of randomized controlled trials

Primary Data Availability
Not applicable

Contact Information
Fotios Barkas: This email address is being protected from spambots. You need JavaScript enabled to view it.